A highly anticipated matchup, or “clash,” between Novak Djokovic and Jan-Lennard Struff is happening during the US Open 2025: Men’s Singles Round of 16, which Djokovic, a seasoned 24-time Grand Slam champion, is going to play during the night at Arthur Ashe Stadium. Struff is being sold at +460 and is desperate to go even further and maybe set history after knocking out seeded players Holger Rune and Frances Tiafoe. It’s no surprise that with Struff’s odds standing at +460, betting on Novak to win is at -600 with an 86% implausible win probability.

In this Djokovic vs. Struff 4th round, we break down the players in the form of head-to-head records, statistics, and expert predictions, in addition to going through the betting odds and how to watch.

Djokovic has a perfect record against Struff, having won all seven of their previous matches. Out of those, six were decided in straight sets, with the only exception being a four-set clash at the 2020 Australian Open. Their latest encounter took place during the 2021 Davis Cup Finals, where Djokovic once again showcased his dominance. With such a strong head-to-head record, Djokovic looks like the favorite, but Struff's recent success and momentum might just give him an opportunity to win a set.

Djokovic has looked strong, but not unbeatable, at the US Open 2025. He’s lost sets in earlier rounds, showing some weakness against younger opponents. His serve and return game, however, are still top-notch. With his sights set on a 25th Grand Slam title, motivation will not be an issue.

Struff qualified and then completed two successive upsets, which he describes as a dream run. He averages more than 13 aces each match, and most of these serves come with a heavy touch. Coupled with his serve, his baseline play has enabled him to bully even the most highly ranked players.

But frequent double faults (6 per match on average) could prove costly against Djokovic’s return game.

Value Bet: The over 35.5 games looks appealing. Djokovic has played some lengthy matches in New York this year. Struff is also known for pushing his opponents into tough battles. A four-set match seems quite likely.

While Djokovic has a perfect 7-0 record against Struff, this match may not be as one-sided as the odds suggest. 

We believe Djokovic will win the match in four sets. Though Struff will certainly put up a fight and may even take a serve, Djokovic’s ability to capitalize on Struff’s double faults will show supremacy as always.

• Best Bet: Djokovic to win 3-1 + Over 35.5 games.

Djokovic vs. Struff clash promises an electric night session at Arthur Ashe. The narrative is inspiring indeed with respect to German qualifiers, but it is highly likely that Djokovic will manage to somehow cross the finish line first on the strength of his skills, mentality, and impeccable record in Grand Slam tournaments. Prediction of the final score: Djokovic wins 3 sets with 1.